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Human Hepatocytes, Cryopreserved, Plateable

Catalog No : HUCPG

Cryopreserved Plateable Human Hepatocytes are characterized for high viability, enzyme activity, and induction potential, allowing their use in DMPK assays. Each ampule contains >5 million viable cells.
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Product Overview

 

Cryopreserved Human Hepatocytes, Plateable format are tested for high viability and healthy culture duration of at least 5 days in 2D sandwich culture. The general purpose plateable hepatocytes are ideal for DMPK studies, disease modeling, genomics applications, and other applications where high quality plated hepatocytes are required.

The general purpose Cryopreserved Human Hepatocytes, Plateable are verified for long-term plating, plating in 96-well format, and for spheroid formation capacity.   

Please download our recent inventory from the link below and look for our Verified for Long TermTM, Verified for 96-wellTM and Verified for SpheroidsTM Characteristics to select your optimal batch.

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Features*:

  • Confluent monolayer with cobblestone morphology, distinct nuclei, and tight junctions for 5 days or more
  • Inducibility of enzyme activity for CYP3A4, CYP2B6, and CYP1A2 
  • Inducibility of mRNA for CYP3A4, CYP2B6, CYP1A2, and CYP2C8 genes
  • Basal metabolism for 8 CYPs, SULT, UGT, and aldehyde oxidase

*Currently, older batches may not have a complete data set of characteristics listed

 

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Benefits

 

  • Large inventory of multiple donors
  • Tested for ability to form spheroids in culture 
  • Tested for long-term applications and 96-well compatibility

 

Applications

 

  • DMPK studies
  • Short term cellular toxicity studies
  • Disease modeling
  • Genomics
  • Xenotransplantation
  • 3D cell culture

 

Storage and Content

1 x Cryopreserved ampule HUCPG containing >5 million viable cells