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DonorPlexTM Pooled Donor Human Hepatocytes, 20 donor, mixed gender

Catalog No : HUCS20P

Pooled donor human hepatocytes that are characterized for multiple CYP450, UGT, SULT, and transporter activities
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Product Overview

 

A consistent and robust source of pooled-donor human hepatocytes is important for DMPK studies. With our new proprietary algorithm we are able to predict yield, viability, and functional phenotype of DonorPlexTM Human Hepatocytes which in turn will support more consistent results in your DMPK. Each batch of pooled 20-donor, mixed-gender human hepatocytes is characterized for viable yield, and CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2E1, CYP3A4, UGT, SULT, OAT1B1/3, OCT, and NTCP activities.

With our large inventory of single-donor human hepatocyte lots, and using our proprietary algorithm to predict phenotype, we can also custom-produce a pooled-donor hepatocyte batch with the phenotype to fit your needs.

The DonorPlexTM Hepatocytes – suspension-qualified hepatocytes are ideally suited for short-term (<4hrs) in vitro drug clearance assays. The suspension-qualified hepatocytes are not suitable for applications that require hepatocytes cultured in adhered monolayer.

 

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Benefits

 

  • Targeted pooling method for predictable metabolism 
  • Precharacterized for 9 CYPs and 4 drug transporters
  • High viability and yields
  • Lot sizes < 2000 are possible

 

Applications

 

  • Suspension metabolism studies

 

Storage and Content

1 x cryopreserved ampule of pooled, suspension-qualified hepatocytes containing >5 million viable cells